Jijo Derick Abraham

About Jijo

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Project details

Quantifying the mechanical properties of myocardium in cases of heart failure by preserved ejection fraction (HFpEF)

Preserved Ejection Fraction (pEF) is a condition in which the heart’s ability to pump blood throughout the body is reduced. It is characterised by a stiffening of the myocardium (cardiac tissue), leading to the heart not relaxing to its full size before contracting for the next heartbeat. This results in a reduction of the actual volume pumped by the heart and, consequently, pEF is present in approximately 50% of people who experience heart failure. The aim of this project is to determine the composite mechanical properties of myocardium that lead to pEF, and identify which component (e.g. titin) dominates these properties. An ongoing area of interest in the study of pEF is the exact way in which the properties of the myocardium change to increase the heart’s relaxation time. A better understanding of how much various tissue properties can change or which specific layers of tissue have the greatest effect on the relaxation could assist in directing treatments towards these problem areas, and focus research on the biological factors that create these changes or effect these areas. This research will be computational in nature. A coupled computational fluid-solid dynamics model will be used to create a digital twin of representative biological flow configurations. The lattice Boltzmann method will be used to model transient blood flow as a non-Newtonian Kuang-Luo fluid, while the finite element method will be used to represent the composite myocardium as a pseudoelastic, orthotropic material. A significant amount of research has been undertaken in computational haemodynamics, while more recent research has been conducted to experimentally determine the material properties of healthy myocardium. By modelling this coupled fluid-solid system, a better understanding of the exact material property changes that are associated with pEF can be achieved, as well as the possibility of exploring treatment methods.

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UQ Supervisor

Dr Christopher Leonardi

School of Mechanical and Mining Engineering
IITD Supervisor

Assistant Professor Bahni Ray

Department of Mechanical Engineering