Microfluidic device for on-chip cell sorting for platelet enrichment

About this project

Project description

Microfluidic technology has come a long way since its advent and now we can carry out various analytical work on a microchip that usually required a large lab and multiple manpower. In this project, we aim to carry out on-chip cell sorting with counting in the same manner as a conventional flow cytometer does, albeit at a microscale and in an automated way using microfluidic technology. Both: IIT Delhi and Queensland University has excellent infrastructure for microfabrication, cell culture and instrumentation/control software development. IITD PI has affiliation with AIIMS New Delhi, where the device shall be validated.

Therefore, in this collaborative work, we are seeking highly motivated and skilled student to work at IIT Delhi for 3 years and one year at University of Queensland. Student shall be enrolled and trained on the aspects like microfabrication, immobilization and stabilization of biorecognition elements on chip, biosensing with suitable transducers (e.g. LIF or dielectrophoresis) and finally clinical validation.

Outcomes

Point of care device for cell sorting and platelet enrichment. Road accident patient or a soldier wounded in battlefield require immediate platelet infusion and has very little time to survive without it. In-situ transfusion from somebody else’s blood would be a challenging but doable research that we are seeking herein.

Information for applicants

Essential capabilities

Chemistry/ Biochemistry/ Biotechnology/ Nanotechnology/ Biomedical Engineering

Desireable capabilities

Microfabrication, Immobilization, Enzyme assay, Biosensing, Microfluidics

Expected qualifications (Course/Degrees etc.)

M.Tech./ M.S./ M.S.R/ M.Sc. in Chemistry/ Biochemistry/ Biotechnology/ Nanotechnology/ Biomedical Engineering

Project supervisors

Principal supervisors

UQ Supervisor

Professor Matt Trau

Australian Institute for Bioengineering and Nanotechnology (AIBN)
IITD Supervisor

Dr Sandeep K. Jha

Department of Biomedical Engineering